Keywords

• intermediates
• novel and diverse
• high-standard quality

Quick Details

• ProName: 3-Hydroxycyclobutanecarbonitrile
• CasNo: 20249-17-6
• Molecular Formula: C5H7NO
• Application: pharmaceutical industry
• DeliveryTime: According to customer requirements
• PackAge: bags;bottles
• Port: in China
• ProductionCapacity: Metric Ton/Day
• Purity: 100%
• Storage: Keep it in cool and dry places.
• Transportation: According to customer requirements
• LimitNum: 1 Kilogram
• Heavy metal: ＜1%
• Grade: Pharma Grade

Superiority

Our R&D center is located in the Hongqiao Science andTechnology Innovation Park, Songjiang District, Shang-hai. The center is fully operated with four chemicalsynthesis laboratories and two kilo-lab laboratories.Our production facilities, located in Shandong, Jiang-su, and Hebei, are capable of handling the productionof advanced pharmaceutical intermediates, rangingfrom 100 kg to metric tons. Over years of dedicatedeffort, FDC has successfully synthesized thousands ofnew molecules and advanced pharmaceutical inter-mediates.And beyond that, we have capability tooffer over 100,000 research chemicals to clientsworldwide. We have established long-term partner-ship with pharmaceutical companies and researchinstitutes globally in Asia, Europe and North Americaetc. We have gained reputation in the industry as anexpertise in custom synthesis, contract research andmanufacturing with efficient operations and high-stan-dard quality control.

KEY CAPABILITIES
Years of unswerving commitment have empowered our R&D team to master pivotal core technologies andsecure essential patents. Our prowess extends to a robust command over R&D. pilot testing. and scale-upamplification in domains like pyridine, pyrimidine, and other heterocyclic compounds. Our dynamic team ofproficient professionals and experts serves as the cornerstone of our positive feedback loop within the R&Dindustrial chain. This dynamic ecosystem fortifies the bedrock upon which our diversified enterprises thriveensuring a trajectory of sustainable qrowth and innovation.

Details

Established in 2010,SHANGHAI FDC-CHEMICALCO.,LTD, specializes in developing pharmaceuti-calsmall molecules and offers CRO &CDMOservices for the global pharmaceutical industry.We provide chemistry services from early drugR&D stage to commercial production, includingsmall scale building block synthesis, pilot-scaleand commercial manufacturing. Our goal is toexpedite the journey of our pharmaceutical partnersfrom preclinical phases to commercial production, byproviding such advanced products and services to theglobal industry.

Our unwavering pursuit is to achieve "Seamlesscollaboration with clients, effective communication,and fulfilling our mission." In the future, FDC willpersist in its business philosophy of "innovation" and"mutually beneficial cooperation," deeply engaging inthe research, development, services, and commercialproduction of novel molecular drugs. We aim to collab-orate with partners worldwide to foster excellence.

Our R&D Center, with space over 1700 square meters.has four fully equipped chemical synthesis laboratoriesand two kilo-lab units. Our dedicated team of over 30researchers has the capacity to simultaneously handlemore than 100 research projects. Our focus is the de.velopment of small molecules for novel drug candi-dates, especially anti-tumor drugs, from innovativesynthesis routes to verification and optimization of production process.Furthermore,our center isequipped with a cutting-edge analysis and testingfacility, a standardized quality control frameworkand an intricately managed warehousing anoogistics system,These comprehensive resourcescollectively contribute to enhancing our customersresearch and developmental processes.

Factory Supply High Purity 99% 20249-17-6 In Bulk Supply

• Molecular Formula:C5H7NO
• Molecular Weight:97.1167
• Boiling Point:70-71 °C(Press: 0.33 Torr) 
• PKA:14.28±0.40(Predicted) 
• PSA：44.02000 
• Density:1.14±0.1 g/cm3(Predicted) 
• LogP:0.28088 

20249-17-6 Relevant articles

AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF

-

Page/Page column 61; 146; 146, (2021/02/26)

Disclosed herein is an aminopyrazine com...

BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF

-

Paragraph 00459, (2020/07/07)

Provided is a novel class of orally and/...

Synthesis of Electron-Deficient Heteroaromatic 1,3-Substituted Cyclobutyls via Zinc Insertion/Negishi Coupling Sequence under Batch and Automated Flow Conditions

Tissot, Matthieu,Body, Nathalie,Petit, Sylvain,Claessens, Jehan,Genicot, Christophe,Pasau, Patrick

supporting information, p. 8022 - 8025 (2019/01/04)

Synthesis of 1,3-substituted cyclobutyls...

ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS

-

, (2017/03/21)

The present disclosure features disclose...

20249-17-6 Process route

20249-16-5

3-oxo-cyclobutanecarbonitrile

20249-17-6,88315-80-4

3-hydroxycyclobutane-1-carbonitrile

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; at 0 ℃; for 0.5h;	92%
With sodium tetrahydroborate; water; In tetrahydrofuran; at -70 ℃; for 1h;	66%
With sodium tetrahydroborate; In tetrahydrofuran; water; at -70 ℃; Cooling with liquid nitrogen;	66%
With sodium tetrahydroborate; In tetrahydrofuran; water; at -70 ℃; for 1h;	66%
With methanol; sodium tetrahydroborate; for 0.5h; Inert atmosphere;	59%
With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h;	4.8 g
With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h;	4.8 g
With methanol; sodium tetrahydroborate; at 20 ℃;	6.5 g
With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

15760-35-7

3-methylenecyclobutanecarbonitrile

20249-17-6,88315-80-4

3-hydroxycyclobutane-1-carbonitrile

Conditions

Conditions	Yield
3-methylenecyclobutanecarbonitrile; With ozone; In methanol; dichloromethane; at -78 ℃; With sodium tetrahydroborate; In methanol; dichloromethane; at -78 - 20 ℃; for 12h; With water; In ethyl acetate;	73%
Multi-step reaction with 2 steps 1: sodium periodate; ruthenium trichloride / water; dichloromethane; acetonitrile / 0 - 20 °C 2: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; In methanol; dichloromethane; water; acetonitrile;
Multi-step reaction with 2 steps 1: sodium periodate; rhodium(III) chloride hydrate / dichloromethane; acetonitrile; water / 8 h 2: methanol; sodium tetrahydroborate / 0.5 h / 0 °C With methanol; sodium tetrahydroborate; sodium periodate; rhodium(III) chloride hydrate; In dichloromethane; water; acetonitrile;
Multi-step reaction with 2 steps 1: ozone / dichloromethane / 0.17 h / -78 °C / Inert atmosphere 2: sodium tetrahydroborate; methanol / 20 °C With methanol; sodium tetrahydroborate; ozone; In dichloromethane;
Multi-step reaction with 2 steps 1: ruthenium(III) trichloride hydrate; sodium periodate / dichloromethane; water; acetonitrile / 2.25 h / 25 °C 2: water; sodium tetrahydroborate / tetrahydrofuran / 1 h / -70 °C With sodium tetrahydroborate; sodium periodate; ruthenium(III) trichloride hydrate; water; In tetrahydrofuran; dichloromethane; water; acetonitrile;
Multi-step reaction with 2 steps 1: ruthenium(III) trichloride hydrate; sodium periodate / dichloromethane; water; acetonitrile / 2.25 h / 10 - 25 °C 2: sodium tetrahydroborate / water; tetrahydrofuran / -70 °C / Cooling with liquid nitrogen With sodium tetrahydroborate; sodium periodate; ruthenium(III) trichloride hydrate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
Multi-step reaction with 2 steps 1: ruthenium(III) trichloride hydrate; sodium periodate / dichloromethane; water; acetonitrile / 2 h / 10 - 25 °C 2: sodium tetrahydroborate / water; tetrahydrofuran / 1 h / -70 °C With sodium tetrahydroborate; sodium periodate; ruthenium(III) trichloride hydrate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
Multi-step reaction with 2 steps 1: ruthenium trichloride; sodium periodate / dichloromethane; water; acetonitrile / 0 - 20 °C 2: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; In methanol; dichloromethane; water; acetonitrile;

20249-17-6 Upstream products

• 
  15760-35-7

  3-methylenecyclobutanecarbonitrile

• 
  20249-16-5

  3-oxo-cyclobutanecarbonitrile

20249-17-6 Downstream products

• 
  938064-64-3

  3-(4-methoxy-benzyloxy)-cyclobutanecarbonitrile

• 
  1544741-03-8

  3-(3,5-dimethylphenoxy)cyclobutanecarbonitrile