Keywords

• intermediates
• novel and diverse
• high-standard quality

Quick Details

• ProName: 2-Aminopteridine-4,7(1H,8H)-dione
• CasNo: 529-69-1
• Molecular Formula: C6H5N5O2
• Application: pharmaceutical industry
• DeliveryTime: According to customer requirements
• PackAge: bags;bottles
• Port: in China
• ProductionCapacity: Metric Ton/Day
• Purity: 97%
• Storage: Keep it in cool and dry places.
• Transportation: According to customer requirements
• LimitNum: 1 Kilogram
• Heavy metal: ＜1%
• Grade: Pharma Grade

Superiority

Our R&D center is located in the Hongqiao Science andTechnology Innovation Park, Songjiang District, Shang-hai. The center is fully operated with four chemicalsynthesis laboratories and two kilo-lab laboratories.Our production facilities, located in Shandong, Jiang-su, and Hebei, are capable of handling the productionof advanced pharmaceutical intermediates, rangingfrom 100 kg to metric tons. Over years of dedicatedeffort, FDC has successfully synthesized thousands ofnew molecules and advanced pharmaceutical inter-mediates.And beyond that, we have capability tooffer over 100,000 research chemicals to clientsworldwide. We have established long-term partner-ship with pharmaceutical companies and researchinstitutes globally in Asia, Europe and North Americaetc. We have gained reputation in the industry as anexpertise in custom synthesis, contract research andmanufacturing with efficient operations and high-stan-dard quality control.

KEY CAPABILITIES
Years of unswerving commitment have empowered our R&D team to master pivotal core technologies andsecure essential patents. Our prowess extends to a robust command over R&D. pilot testing. and scale-upamplification in domains like pyridine, pyrimidine, and other heterocyclic compounds. Our dynamic team ofproficient professionals and experts serves as the cornerstone of our positive feedback loop within the R&Dindustrial chain. This dynamic ecosystem fortifies the bedrock upon which our diversified enterprises thriveensuring a trajectory of sustainable qrowth and innovation.

Details

Established in 2010,SHANGHAI FDC-CHEMICALCO.,LTD, specializes in developing pharmaceuti-calsmall molecules and offers CRO &CDMOservices for the global pharmaceutical industry.We provide chemistry services from early drugR&D stage to commercial production, includingsmall scale building block synthesis, pilot-scaleand commercial manufacturing. Our goal is toexpedite the journey of our pharmaceutical partnersfrom preclinical phases to commercial production, byproviding such advanced products and services to theglobal industry.

Our unwavering pursuit is to achieve "Seamlesscollaboration with clients, effective communication,and fulfilling our mission." In the future, FDC willpersist in its business philosophy of "innovation" and"mutually beneficial cooperation," deeply engaging inthe research, development, services, and commercialproduction of novel molecular drugs. We aim to collab-orate with partners worldwide to foster excellence.

Our R&D Center, with space over 1700 square meters.has four fully equipped chemical synthesis laboratoriesand two kilo-lab units. Our dedicated team of over 30researchers has the capacity to simultaneously handlemore than 100 research projects. Our focus is the de.velopment of small molecules for novel drug candi-dates, especially anti-tumor drugs, from innovativesynthesis routes to verification and optimization of production process.Furthermore,our center isequipped with a cutting-edge analysis and testingfacility, a standardized quality control frameworkand an intricately managed warehousing anoogistics system,These comprehensive resourcescollectively contribute to enhancing our customersresearch and developmental processes.

Quality Factory Supply Hot Sale 2-Aminopteridine-4,7(1H,8H)-dione On Stock

• Molecular Formula:C6H5N5O2
• Molecular Weight:179.138
• Vapor Pressure:1.76E-19mmHg at 25°C 
• Melting Point:>300 °C 
• Refractive Index:1.991 
• Boiling Point:686.5 °C at 760 mmHg 
• PKA:11.32±0.20(Predicted) 
• Flash Point:369 °C 
• PSA：117.52000 
• Density:2.176 g/cm³ 
• LogP:-0.83020 

ISOXANTHOPTERIN(Cas 529-69-1) Usage

Synthesis Reference(s)	Journal of the American Chemical Society, 75, p. 4450, 1953 DOI: 10.1021/ja01114a016
Biological Activity	isoxanthopterin interferes with rna and dna synthesis.isoxanthopterin, a natural intermediate in the pteridine pathway, plays critical roles in pigmentation and cell division.
in vitro	isoxanthopterin was identified as a pteridine of wide natural occurrence and was reported to exerts an inhibitory action on the synthesis of ribosomal rna, possibly soluble rna and on dna in developing eggs of the milkweed bug oncopeltus fasciatus. such effects were measured by partially incubating dechorionated eggs in a solution containing isoxanthopterin and radioactive uridine or thymidine, and then testing the incorporation of the isotope into ribosomal rna or dna. the detailed mechanism of this inhibition had been discussed, and the tentative conclusion was agreed that it was due to an interaction between the pteridine and the nucleic acid (most probably dna) [1].
in vivo	previous animal study showed that rats with inherited retinal dystrophy appeared to differ from healthy rats by an elevated isoxanthopterin excretion in urine. rcs rats responded to feeding of monapterin with an increase of isoxanthopterin excretion. this phenomenon supported the idea that the rcs rat had an increased xanthinoxidase activity compared with healthy rats [2].
Purification Methods	Purify it by repeated precipitation from alkaline solution with acid (preferably AcOH or formic acid), filter, wash well with H2O, then EtOH and dry at 100o. The purity is checked by paper chromatography [RF 0.15 (n-BuOH/AcOH/H2O, 4:1:1); 0.33 (3% aqueous NH4OH). [Goto et al. Arch Biochem Biophys 111 8 1965.] [For biochemistry see Blakley Biochemistry of Folic Acid and Related Pteridines North Holland Publ Co, Amsterdam 1969.] [Beilstein 26 III/IV 3999.]
references	[1] lagowski, j. m. and forrest, h.s. interaction in vitro between isoxanthopterin and dna. proceedings of the national academy of sciences of the united states of america 58(4), 1541-1547 (1967).[2] g. cremer-bartels, h. gerding, l. hanneken and k. krause. isoxanthopterin excretion of rats with inherited retinal dystrophy. pteridines vol. 2, 1990, pp. 103 -105.

InChI:InChI=1/C6H5N5O2/c7-6-10-4-3(5(13)11-6)8-1-2(12)9-4/h1H,(H4,7,9,10,11,12,13)

529-69-1 Relevant articles

Regulation of xanthine oxidase activity by substrates at active sites via cooperative interactions between catalytic subunits: Implication to drug pharmacokinetics

Tai,Hwang

experimental part, p. 69 - 78 (2012/01/05)

Three xanthine oxidase substrates (i.e.,...

Enzymatic inhibition assay for fluorometric determination of allopurinol and oxipurinol in serum and urine

Neubert,Besenfelder,Koch

, p. 1857 - 1859 (2007/10/02)

An enzymatic inhibition assay for the xa...

The chemical degradation of folic acid. Photolysis of 2,4,7-trihydroxypteridine.

Shaw,Baugh,Krumdieck

, p. 379 - 382 (2007/10/09)

-

529-69-1 Process route

117123-36-1

(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylimino)-acetic acid ethyl ester

529-69-1

isoxanthopterin

Conditions

Conditions	Yield
With sodium hydrogencarbonate;
With ammonium hydroxide;

3254-85-1

2-amino-4,7-dioxo-3,4,7,8-tetrahydro-pteridine-6-carboxylic acid

529-69-1

isoxanthopterin

Conditions

Conditions	Yield

529-69-1 Upstream products

• 
  117123-36-1

  (2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylimino)-acetic acid ethyl ester

• 
  3254-85-1

  2-amino-4,7-dioxo-3,4,7,8-tetrahydro-pteridine-6-carboxylic acid

• 
  2236-60-4

  pterin

529-69-1 Downstream products

• 
  2817-14-3

  5,8-dihydro-1H-pteridine-2,4,6,7-tetraone